4N1U

Structure of human MTH1 in complex with TH588

4N1U の概要

• エントリーDOI: 10.2210/pdb4n1u/pdb
• 関連するPDBエントリー: 3ZR0 3ZR1 4N1T
• 分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: oxidised nucleotide degradation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38052.30

構造登録者

Berntsson, R.P.-A.,Jemth, A.,Gustafsson, R.,Svensson, L.M.,Helleday, T.,Stenmark, P. (登録日: 2013-10-04, 公開日: 2014-04-16, 最終更新日: 2023-09-20)

• 主引用文献: Gad, H.,Koolmeister, T.,Jemth, A.S.,Eshtad, S.,Jacques, S.A.,Strom, C.E.,Svensson, L.M.,Schultz, N.,Lundback, T.,Einarsdottir, B.O.,Saleh, A.,Gokturk, C.,Baranczewski, P.,Svensson, R.,Berntsson, R.P.,Gustafsson, R.,Stromberg, K.,Sanjiv, K.,Jacques-Cordonnier, M.C.,Desroses, M.,Gustavsson, A.L.,Olofsson, R.,Johansson, F.,Homan, E.J.,Loseva, O.,Brautigam, L.,Johansson, L.,Hoglund, A.,Hagenkort, A.,Pham, T.,Altun, M.,Gaugaz, F.Z.,Vikingsson, S.,Evers, B.,Henriksson, M.,Vallin, K.S.,Wallner, O.A.,Hammarstrom, L.G.,Wiita, E.,Almlof, I.,Kalderen, C.,Axelsson, H.,Djureinovic, T.,Puigvert, J.C.,Haggblad, M.,Jeppsson, F.,Martens, U.,Lundin, C.,Lundgren, B.,Granelli, I.,Jensen, A.J.,Artursson, P.,Nilsson, J.A.,Stenmark, P.,Scobie, M.,Berglund, U.W.,Helleday, T.; MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.; Nature, 508:215-221, 2014; PubMed: 24695224; DOI: 10.1038/nature13181

実験手法

X-RAY DIFFRACTION (1.6 Å)