4N1U
Structure of human MTH1 in complex with TH588
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 7,8-dihydro-8-oxoguanine triphosphatase | polymer | 158 | 18154.6 | 2 | UniProt (P36639) Pfam (PF00293) | Homo sapiens (human) | 2-hydroxy-dATP diphosphatase, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1 |
| 2 | C, K (A, B) | N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine | non-polymer | 295.2 | 2 | Chemie (2GE) | |||
| 3 | D, E, F, G, H... (A, B) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 4 | Q, R (A, B) | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 155 (UniProt: P36639)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36309.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1743.1 | |
| All* | Total formula weight | 38052.3 |
