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4N1U

Structure of human MTH1 in complex with TH588

Functional Information from GO Data
ChainGOidnamespacecontents
A0001669cellular_componentacrosomal vesicle
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0006281biological_processDNA repair
A0006979biological_processresponse to oxidative stress
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008584biological_processmale gonad development
A0008828molecular_functiondATP diphosphatase activity
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0031965cellular_componentnuclear membrane
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0001669cellular_componentacrosomal vesicle
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0006281biological_processDNA repair
B0006979biological_processresponse to oxidative stress
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008584biological_processmale gonad development
B0008828molecular_functiondATP diphosphatase activity
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0031965cellular_componentnuclear membrane
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 2GE A 201
ChainResidue
ATHR8
APHE27
AASN33
APHE72
ATRP117
AASP119
AASP120
ATRP123
APHE139

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 202
ChainResidue
ALEU9
ALYS23
AGLY34
AGLY36
AGLU56
AMET101
AHOH304

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 203
ChainResidue
AGLU77
BHIS65
BLYS66
BLYS132
BSO4204

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 204
ChainResidue
ATYR122
ATYR148
AHOH335
BLYS24
BTYR136
BLYS138
BSO4203

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 205
ChainResidue
AALA63
AHIS65
ATHR88
AASP89
ASER90
AHOH354
BGLN142

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 206
ChainResidue
ALYS23
AGLY26
APHE27
BLYS114

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 207
ChainResidue
ALYS66
AHIS134
BARG17
BHOH330

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 208
ChainResidue
APHE113
ASER121
APRO125

site_idAC9
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 2GE B 201
ChainResidue
BTYR7
BTHR8
BPHE27
BASN33
BPHE72
BPHE74
BMET81
BTRP117
BASP119
BASP120
BTRP123
BPHE139
BSO4202
BHOH369

site_idBC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 B 202
ChainResidue
BLYS23
BASN33
BGLY34
BGLY36
BGLU56
BGLU100
BMET101
B2GE201
BHOH307

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 203
ChainResidue
ATYR122
AILE145
ASO4204
BLYS24
BGLU97
BSER98
BASP99

site_idBC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 204
ChainResidue
APHE27
APHE74
AGLU77
AGLY141
AGLN142
ASO4203
BHIS65

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 205
ChainResidue
ASER121
ATYR122
BARG25
BASP99

site_idBC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 B 206
ChainResidue
AGLN142
BALA63
BHIS65
BTHR88
BASP89
BSER90
BHOH352
BHOH401

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG
ChainResidueDetails
AGLY37-GLY58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7ZWC3
ChainResidueDetails
ALEU11
AGLN14
APRO15
ALEU59
BLEU11
BGLN14
BPRO15
BLEU59

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30304478, ECO:0007744|PDB:5OTM
ChainResidueDetails
AGLY76
BGLY76

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PDB entries from 2024-11-20

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