4N0E

Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP

Summary for 4N0E

Entry DOI	10.2210/pdb4n0e/pdb
Related	1AS3 1BOF 1GDD 2ZJZ 3FFB 4N0D
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ... (4 entities in total)
Functional Keywords	rossmann fold, guanine nucleotide binding protein, gdp, gtp, magnesium binding, hydrolase
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Nucleus: P10824
Total number of polymer chains	1
Total formula weight	41066.40
Authors	Thaker, T.M.,Preininger, A.M.,Sarwar, M.,Hamm, H.E.,Iverson, T.M. (deposition date: 2013-10-01, release date: 2014-03-12, Last modification date: 2023-09-20)
Primary citation	Thaker, T.M.,Sarwar, M.,Preininger, A.M.,Hamm, H.E.,Iverson, T.M. A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1. J.Biol.Chem., 289:11331-11341, 2014 Cited by PubMed: 24596087 DOI: 10.1074/jbc.M113.539064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation