4MZS
Mouse cathepsin s with covalent ligand (3S,4S)-1-[(2-CHLOROPHENYL)SULFONYL]-N-[(2E)-2-IMINOETHYL]-4-(MORPHOLIN-4-YLCARBONYL)PYRROLIDINE-3-CARBOXAMIDE
Summary for 4MZS
Entry DOI | 10.2210/pdb4mzs/pdb |
Related | 4BS5 4BSQ 4MZO |
Descriptor | Cathepsin S, (3S,4S)-1-[(2-chlorophenyl)sulfonyl]-N-[(2E)-2-iminoethyl]-4-(morpholin-4-ylcarbonyl)pyrrolidine-3-carboxamide (3 entities in total) |
Functional Keywords | hydrolase, cysteine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Lysosome: O70370 |
Total number of polymer chains | 2 |
Total formula weight | 50210.79 |
Authors | Kuglstatter, A.,Stihle, M. (deposition date: 2013-09-30, release date: 2014-08-20, Last modification date: 2023-09-20) |
Primary citation | Hilpert, H.,Mauser, H.,Humm, R.,Anselm, L.,Kuehne, H.,Hartmann, G.,Gruener, S.,Banner, D.W.,Benz, J.,Gsell, B.,Kuglstatter, A.,Stihle, M.,Thoma, R.,Sanchez, R.A.,Iding, H.,Wirz, B.,Haap, W. Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds. J.Med.Chem., 56:9789-9801, 2013 Cited by PubMed: 24224654DOI: 10.1021/jm401528k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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