4BS5
MOUSE CATHEPSIN S WITH COVALENT LIGAND
Summary for 4BS5
Entry DOI | 10.2210/pdb4bs5/pdb |
Related | 4BQV 4BS6 4BSQ |
Descriptor | CATHEPSIN S, (2S,4R)-N-[1-(iminomethyl)cyclopropyl]-4-[2-(trifluoromethyl)phenyl]sulfonyl-pyrrolidine-2-carboxamide (3 entities in total) |
Functional Keywords | hydrolase, cysteine protease, covalent ligand |
Biological source | MUS MUSCULUS (HOUSE MOUSE) |
Cellular location | Lysosome: O70370 |
Total number of polymer chains | 1 |
Total formula weight | 25051.87 |
Authors | Banner, D.W.,Benz, J.,Gsell, B.,Stihle, M.,Ruf, A.,Haap, W. (deposition date: 2013-06-07, release date: 2013-11-27, Last modification date: 2024-05-01) |
Primary citation | Hilpert, H.,Mauser, H.,Humm, R.,Anselm, L.,Kuehne, H.,Hartmann, G.,Gruener, S.,Banner, D.W.,Benz, J.,Gsell, B.,Kuglstatter, A.,Stihle, M.,Thoma, R.,Alvarez-Sanchez, R.,Iding, H.,Wirz, B.,Haap, W. Identification of Potent and Selective Cathepsin S (Cats) Inhibitors Containing Different Central Cyclic Scaffolds. J.Med.Chem., 56:9789-, 2013 Cited by PubMed: 24224654DOI: 10.1021/JM401528K PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
Download full validation report