4MX5

Structure of ricin A chain bound with benzyl-(2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)ethyl)carbamate

Summary for 4MX5

Entry DOI	10.2210/pdb4mx5/pdb
Related	1BR6 1IFT 1RTC 3PX8 4HUP 4MX1
Descriptor	Ricin A chain, benzyl (2-{[(2-amino-4-oxo-3,4-dihydropteridin-7-yl)carbonyl]amino}ethyl)carbamate (3 entities in total)
Functional Keywords	toxin, hydrolase, ribosome-inactivating protein, n-glycosidase, pterin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Ricinus communis (Castor bean)
Total number of polymer chains	1
Total formula weight	30451.31
Authors	Jasheway, K.R.,Robertus, J.D.,Wiget, P.A.,Manzano, L.A.,Pruet, J.M.,Gao, G.,Saito, R.,Monzingo, A.F.,Anslyn, E.V. (deposition date: 2013-09-25, release date: 2014-01-15, Last modification date: 2023-09-20)
Primary citation	Wiget, P.A.,Manzano, L.A.,Pruet, J.M.,Gao, G.,Saito, R.,Monzingo, A.F.,Jasheway, K.R.,Robertus, J.D.,Anslyn, E.V. Sulfur incorporation generally improves Ricin inhibition in pterin-appended glycine-phenylalanine dipeptide mimics. Bioorg.Med.Chem.Lett., 23:6799-6804, 2013 Cited by PubMed: 24432385 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation