4MX5

Structure of ricin A chain bound with benzyl-(2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)ethyl)carbamate

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0017148	biological_process	negative regulation of translation
X	0030598	molecular_function	rRNA N-glycosylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 5MX X 301

Chain	Residue
X	ALA79
X	ARG180
X	HOH451
X	HOH511
X	HOH540
X	HOH612
X	HOH628
X	TYR80
X	VAL81
X	PHE93
X	GLY121
X	ASN122
X	TYR123
X	ILE172
X	SER176

---

Functional Information from PROSITE/UniProt

site_id	PS00275
Number of Residues	17
Details	SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMIsEAARFQyIEgeM

Chain	Residue	Details
X	ILE172-MET188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P84531

Chain	Residue	Details
X	TYR80
X	TYR123
X	GLU177
X	ARG180

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
X	ILE8

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
X	GLY15
X	GLY50
X	ASN141
X	ASN195

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8780513, ECO:0007744|PDB:1OBT

Chain	Residue	Details
X	TYR80
X	GLY121

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1368517

Chain	Residue	Details
X	ASN10

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:1368517

Chain	Residue	Details
X	ASN236

---