4MWS

Crystal structure of human PPCA (trigonal crystal form 1)

Summary for 4MWS

Entry DOI	10.2210/pdb4mws/pdb
Related	1IVY 4MWT
Descriptor	Lysosomal protective protein, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	cathepsin a, glycoprotein, serine protease, carboxypeptidase, protective protein, n-linked glycosylation, proteolytically activated form, lysosomal enzyme, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	99565.27
Authors	Kolli, N.,Garman, S.C. (deposition date: 2013-09-25, release date: 2014-03-12, Last modification date: 2023-09-20)
Primary citation	Kolli, N.,Garman, S.C. Proteolytic activation of human cathepsin A. J.Biol.Chem., 289:11592-11600, 2014 Cited by PubMed: 24599961 DOI: 10.1074/jbc.M113.524280 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation