4MWS
Crystal structure of human PPCA (trigonal crystal form 1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lysosomal protective protein | polymer | 428 | 48655.6 | 2 | UniProt (P10619) Pfam (PF00450) | Homo sapiens (human) | Carboxypeptidase C, Carboxypeptidase L, Cathepsin A, Protective protein cathepsin A, PPCA, Protective protein for beta-galactosidase |
| 2 | C (C) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G17689EW) | |||
| 3 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G18638YB) | |||
| 4 | E, G (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | F, H (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 452 (UniProt: P10619)
| PDB | External Database | Details |
|---|---|---|
| - | Tyr 291 | deletion |
| - | Glu 292 | deletion |
| - | Lys 293 | deletion |
| - | Asp 294 | deletion |
| - | Thr 295 | deletion |
| - | Val 296 | deletion |
| - | Val 297 | deletion |
| - | Val 298 | deletion |
| - | Gln 299 | deletion |
| - | Asp 300 | deletion |
| - | Leu 301 | deletion |
| - | Gly 302 | deletion |
| - | Asn 303 | deletion |
| - | Ile 304 | deletion |
| - | Phe 305 | deletion |
| - | Thr 306 | deletion |
| - | Arg 307 | deletion |
| - | Leu 308 | deletion |
| - | Pro 309 | deletion |
| - | Leu 310 | deletion |
| - | Lys 311 | deletion |
| - | Arg 312 | deletion |
| - | Met 313 | deletion |
| - | Trp 314 | deletion |
| - | His 315 | deletion |
| - | Gln 316 | deletion |
| - | Ala 317 | deletion |
| - | Leu 318 | deletion |
| - | Leu 319 | deletion |
| - | Arg 320 | deletion |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
| His 456 | - | expression tag |
| His 457 | - | expression tag |
| His 458 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97311.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1627.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 626.6 | |
| All* | Total formula weight | 99565.3 |
