4MVH

Crystal Structure of PDE10A with Novel Keto-Benzimidazole Inhibitor

Summary for 4MVH

• Entry DOI: 10.2210/pdb4mvh/pdb
• Related: 4MUW
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: pde10a, phosphodiesterase 10a, inhibitors, keto-benzimidazoles, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 83368.02

Authors

Chmait, S.,Jordan, S. (deposition date: 2013-09-24, release date: 2013-10-23, Last modification date: 2014-01-15)

• Primary citation: Hu, E.,Kunz, R.K.,Chen, N.,Rumfelt, S.,Siegmund, A.,Andrews, K.,Chmait, S.,Zhao, S.,Davis, C.,Chen, H.,Lester-Zeiner, D.,Ma, J.,Biorn, C.,Shi, J.,Porter, A.,Treanor, J.,Allen, J.R.; Design, Optimization, and Biological Evaluation of Novel Keto-Benzimidazoles as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).; J.Med.Chem., 56:8781-8792, 2013; PubMed: 24102193; DOI: 10.1021/jm401234w

Experimental method

X-RAY DIFFRACTION (2.496 Å)