Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | HIS519 |
| A | HIS553 |
| A | ASP554 |
| A | ASP664 |
| A | ZN1002 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN A 1002 |
| Chain | Residue |
| A | ASP554 |
| A | ZN1001 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | ASN474 |
| A | MET475 |
| A | ARG510 |
| A | ARG558 |
| A | HIS570 |
| A | PHE472 |
| A | GLU473 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | LYS497 |
| A | GLY597 |
| A | HIS598 |
| A | ASN599 |
| A | HOH1159 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | ASN647 |
| A | ARG652 |
| B | LEU537 |
| B | LEU646 |
| B | ASN647 |
| B | ARG652 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | ARG510 |
| A | ARG511 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1007 |
| Chain | Residue |
| A | SER577 |
| A | THR578 |
| A | GLN583 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1008 |
| Chain | Residue |
| A | ASN508 |
| A | GLN588 |
| A | SER591 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1009 |
| Chain | Residue |
| A | ASP468 |
| A | LYS518 |
| A | THR678 |
| A | LYS695 |
| A | HOH1144 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 2F5 A 1010 |
| Chain | Residue |
| A | TYR514 |
| A | SER667 |
| A | VAL668 |
| A | ILE682 |
| A | TYR683 |
| A | PHE686 |
| A | PRO702 |
| A | MET703 |
| A | LYS708 |
| A | GLY715 |
| A | GLN716 |
| A | PHE719 |
| A | HOH1140 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 801 |
| Chain | Residue |
| B | HIS519 |
| B | HIS553 |
| B | ASP554 |
| B | ASP664 |
| B | ZN802 |
| B | HOH901 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 802 |
| Chain | Residue |
| B | ASP554 |
| B | ZN801 |
| B | HOH927 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 803 |
| Chain | Residue |
| B | PHE472 |
| B | GLU473 |
| B | ASN474 |
| B | MET475 |
| B | ARG510 |
| B | ARG558 |
| B | HIS570 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 804 |
| Chain | Residue |
| B | ARG510 |
| B | ARG511 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 805 |
| Chain | Residue |
| B | LYS497 |
| B | GLY597 |
| B | HIS598 |
| B | ASN599 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 806 |
| Chain | Residue |
| A | ASN645 |
| A | ASN647 |
| A | ASN648 |
| B | THR539 |
| B | ASP540 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 807 |
| Chain | Residue |
| B | ASN508 |
| B | GLN588 |
| B | SER591 |
| B | ILE592 |
| site_id | BC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2F5 B 808 |
| Chain | Residue |
| B | SER667 |
| B | VAL668 |
| B | ILE682 |
| B | TYR683 |
| B | PHE686 |
| B | PRO702 |
| B | MET703 |
| B | GLU711 |
| B | VAL712 |
| B | GLY715 |
| B | GLN716 |
| B | PHE719 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS553-TYR564 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]} |
