4MSU
Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate
Summary for 4MSU
Entry DOI | 10.2210/pdb4msu/pdb |
Descriptor | Glucokinase regulatory protein, 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total) |
Functional Keywords | sis domains, regulatory protein, glucokinase, phospho-fructose, sugar binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): Q14397 |
Total number of polymer chains | 2 |
Total formula weight | 145033.18 |
Authors | Ashton, K.S.,Andrews, K.L.,Bryan, M.C.,Chen, J.,Chen, K.,Chen, M.,Chmait, S.,Croghan, M.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kurzeja, R.J.,Michelsen, K.,Pennington, L.D.,Poon, S.F.,Sivits, G.,Van, G.,Vonderfecht, S.L.,Wahl, R.C.,Zhang, J.,Lloyd, D.J.,Hale, C.,St Jean, D.J. (deposition date: 2013-09-18, release date: 2014-03-12, Last modification date: 2024-02-28) |
Primary citation | Ashton, K.S.,Andrews, K.L.,Bryan, M.C.,Chen, J.,Chen, K.,Chen, M.,Chmait, S.,Croghan, M.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kurzeja, R.J.,Michelsen, K.,Pennington, L.D.,Poon, S.F.,Sivits, G.,Van, G.,Vonderfecht, S.L.,Wahl, R.C.,Zhang, J.,Lloyd, D.J.,Hale, C.,St Jean, D.J. Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept. J.Med.Chem., 57:309-324, 2014 Cited by PubMed: 24405172DOI: 10.1021/jm4016735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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