4MSU

Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate

4MSU の概要

• エントリーDOI: 10.2210/pdb4msu/pdb
• 分子名称: Glucokinase regulatory protein, 1,1,1,3,3,3-hexafluoro-2-{4-[4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: sis domains, regulatory protein, glucokinase, phospho-fructose, sugar binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): Q14397
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 145033.18

構造登録者

Ashton, K.S.,Andrews, K.L.,Bryan, M.C.,Chen, J.,Chen, K.,Chen, M.,Chmait, S.,Croghan, M.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kurzeja, R.J.,Michelsen, K.,Pennington, L.D.,Poon, S.F.,Sivits, G.,Van, G.,Vonderfecht, S.L.,Wahl, R.C.,Zhang, J.,Lloyd, D.J.,Hale, C.,St Jean, D.J. (登録日: 2013-09-18, 公開日: 2014-03-12, 最終更新日: 2024-02-28)

• 主引用文献: Ashton, K.S.,Andrews, K.L.,Bryan, M.C.,Chen, J.,Chen, K.,Chen, M.,Chmait, S.,Croghan, M.,Cupples, R.,Fotsch, C.,Helmering, J.,Jordan, S.R.,Kurzeja, R.J.,Michelsen, K.,Pennington, L.D.,Poon, S.F.,Sivits, G.,Van, G.,Vonderfecht, S.L.,Wahl, R.C.,Zhang, J.,Lloyd, D.J.,Hale, C.,St Jean, D.J.; Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept.; J.Med.Chem., 57:309-324, 2014; PubMed: 24405172; DOI: 10.1021/jm4016735

実験手法

X-RAY DIFFRACTION (2.5 Å)