4MR6
Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-208)
4MR6 の概要
エントリーDOI | 10.2210/pdb4mr6/pdb |
分子名称 | Bromodomain-containing protein 2, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... (5 entities in total) |
機能のキーワード | brd2, ring3, small molecule inhibitor, rvx-208, inhibitor complex, structural genomics consortium, sgc, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus (Probable): P25440 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 14010.15 |
構造登録者 | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2013-09-17, 公開日: 2013-11-27, 最終更新日: 2023-09-20) |
主引用文献 | Picaud, S.,Wells, C.,Felletar, I.,Brotherton, D.,Martin, S.,Savitsky, P.,Diez-Dacal, B.,Philpott, M.,Bountra, C.,Lingard, H.,Fedorov, O.,Muller, S.,Brennan, P.E.,Knapp, S.,Filippakopoulos, P. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc.Natl.Acad.Sci.USA, 110:19754-19759, 2013 Cited by PubMed: 24248379DOI: 10.1073/pnas.1310658110 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.67 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード