4MNW

Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK749

Summary for 4MNW

• Entry DOI: 10.2210/pdb4mnw/pdb
• Related: 2NWN 3QN7 4GLY 4JK5 4JK6 4MNV 4MNX 4MNY
• Related PRD ID: PRD_001166
• Descriptor: Urokinase-type plasminogen activator chain B, bicyclic peptide UK749, SULFATE ION, ... (7 entities in total)
• Functional Keywords: competitive inhibitor, bicyclic peptide, inhibitor, protease, 1, 3, 5-tris(bromomethyl)benzene (tbmb) cyclization, extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00749
• Total number of polymer chains: 2
• Total formula weight: 30267.76

Authors

Chen, S.,Pojer, F.,Heinis, C. (deposition date: 2013-09-11, release date: 2014-02-05, Last modification date: 2017-11-15)

• Primary citation: Chen, S.,Bertoldo, D.,Angelini, A.,Pojer, F.,Heinis, C.; Peptide ligands stabilized by small molecules.; Angew.Chem.Int.Ed.Engl., 53:1602-1606, 2014; PubMed: 24453110; DOI: 10.1002/anie.201309459

Experimental method

X-RAY DIFFRACTION (1.49 Å)