4MNV
Crystal structure of bicyclic peptide UK729 bound as an acyl-enzyme intermediate to urokinase-type plasminogen activator (uPA)
Summary for 4MNV
Entry DOI | 10.2210/pdb4mnv/pdb |
Related | 2NWN 3QN7 4GLY 4JK5 4JK6 4MNW 4MNX 4MNY |
Descriptor | Urokinase-type plasminogen activator chain B, acyl-enzyme intermediate of bicyclic peptide UK729, SULFATE ION, ... (8 entities in total) |
Functional Keywords | acyl-enzyme intermediate, inhibitor, protease, 1, 3, 5-tris(bromomethyl)benzene (tbmb) cyclization, extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 3 |
Total formula weight | 29725.31 |
Authors | Chen, S.,Pojer, F.,Heinis, C. (deposition date: 2013-09-11, release date: 2014-02-05, Last modification date: 2017-11-15) |
Primary citation | Chen, S.,Bertoldo, D.,Angelini, A.,Pojer, F.,Heinis, C. Peptide ligands stabilized by small molecules. Angew.Chem.Int.Ed.Engl., 53:1602-1606, 2014 Cited by PubMed: 24453110DOI: 10.1002/anie.201309459 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report