4MNV

Crystal structure of bicyclic peptide UK729 bound as an acyl-enzyme intermediate to urokinase-type plasminogen activator (uPA)

4MNV の概要

• エントリーDOI: 10.2210/pdb4mnv/pdb
• 関連するPDBエントリー: 2NWN 3QN7 4GLY 4JK5 4JK6 4MNW 4MNX 4MNY
• 分子名称: Urokinase-type plasminogen activator chain B, acyl-enzyme intermediate of bicyclic peptide UK729, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: acyl-enzyme intermediate, inhibitor, protease, 1, 3, 5-tris(bromomethyl)benzene (tbmb) cyclization, extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00749
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 29725.31

構造登録者

Chen, S.,Pojer, F.,Heinis, C. (登録日: 2013-09-11, 公開日: 2014-02-05, 最終更新日: 2017-11-15)

• 主引用文献: Chen, S.,Bertoldo, D.,Angelini, A.,Pojer, F.,Heinis, C.; Peptide ligands stabilized by small molecules.; Angew.Chem.Int.Ed.Engl., 53:1602-1606, 2014; PubMed: 24453110; DOI: 10.1002/anie.201309459

実験手法

X-RAY DIFFRACTION (1.8 Å)