4MNQ

TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions

4MNQ の概要

• エントリーDOI: 10.2210/pdb4mnq/pdb
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Telomerase reverse transcriptase, ... (8 entities in total)
• 機能のキーワード: surface plasmon resonance (spr); biacoretm; peptide-major histocompatibility complex (pmhc): t-cell receptor (tcr), t-cells; high affinity tcr, two-step binding, adoptive therapy, immunoglobulin, adaptive immune response, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted . Note=(Microbial infection) In the presence of M: P61769; Nucleus, nucleolus : O14746; Membrane ; Single-pass membrane protein : P01850
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 94569.98

構造登録者

Rizkallah, P.J.,Cole, D.K.,Sewell, A.K.,Jakobsen, B.K. (登録日: 2013-09-11, 公開日: 2013-11-13, 最終更新日: 2017-08-02)

• 主引用文献: Cole, D.K.,Miles, K.M.,Madura, F.,Holland, C.J.,Schauenburg, A.J.,Godkin, A.J.,Bulek, A.M.,Fuller, A.,Akpovwa, H.J.,Pymm, P.G.,Liddy, N.,Sami, M.,Li, Y.,Rizkallah, P.J.,Jakobsen, B.K.,Sewell, A.K.; T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.; J.Biol.Chem., 289:628-638, 2014; PubMed: 24196962; DOI: 10.1074/jbc.M113.522110

実験手法

X-RAY DIFFRACTION (2.742 Å)