4MM3
Crystal structure of SARS-CoV papain-like protease PLpro in complex with ubiquitin aldehyde
Summary for 4MM3
Entry DOI | 10.2210/pdb4mm3/pdb |
Related | 1UBQ 2FE8 |
Descriptor | Ubiquitin, Papain-like proteinase, ZINC ION, ... (4 entities in total) |
Functional Keywords | nsp3 papain-like protease domain, signaling protein-hydrolase complex, signaling protein/hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Ubiquitin: Cytoplasm : P0CG48 Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8 |
Total number of polymer chains | 2 |
Total formula weight | 44146.51 |
Authors | Mesecar, A.D.,Ratia, K. (deposition date: 2013-09-08, release date: 2014-07-02, Last modification date: 2017-11-15) |
Primary citation | Ratia, K.,Kilianski, A.,Baez-Santos, Y.M.,Baker, S.C.,Mesecar, A. Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease. Plos Pathog., 10:e1004113-e1004113, 2014 Cited by PubMed: 24854014DOI: 10.1371/journal.ppat.1004113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.752 Å) |
Structure validation
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