4MLL

The 1.4 A structure of the class D beta-lactamase OXA-1 K70D complexed with oxacillin

Replaces:  4F7Y

Summary for 4MLL

• Entry DOI: 10.2210/pdb4mll/pdb
• Related: 4F94
• Descriptor: Beta-lactamase OXA-1, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: hydrolase, oxacillinase, antibiotic resistance, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Escherichia coli
• Total number of polymer chains: 4
• Total formula weight: 115220.08

Authors

June, C.M.,Vallier, B.C.,Bonomo, R.A.,Leonard, D.A.,Powers, R.A. (deposition date: 2013-09-06, release date: 2013-10-09, Last modification date: 2023-09-20)

• Primary citation: June, C.M.,Vallier, B.C.,Bonomo, R.A.,Leonard, D.A.,Powers, R.A.; Structural Origins of Oxacillinase Specificity in Class D beta-Lactamases.; Antimicrob.Agents Chemother., 58:333-341, 2014; PubMed: 24165180; DOI: 10.1128/AAC.01483-13

Experimental method

X-RAY DIFFRACTION (1.37 Å)