4MJH

Human Hsp27 core domain in complex with C-terminal peptide

Summary for 4MJH

• Entry DOI: 10.2210/pdb4mjh/pdb
• Descriptor: Heat shock protein beta-1 (3 entities in total)
• Functional Keywords: small heat shock protein, cancer, amyloid, chaperone
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : P04792 P04792
• Total number of polymer chains: 4
• Total formula weight: 22533.18

Authors

Laganowsky, A.,Cascio, D.,Sawaya, M.R.,Eisenberg, D. (deposition date: 2013-09-03, release date: 2014-04-09, Last modification date: 2024-02-28)

• Primary citation: Hochberg, G.K.,Ecroyd, H.,Liu, C.,Cox, D.,Cascio, D.,Sawaya, M.R.,Collier, M.P.,Stroud, J.,Carver, J.A.,Baldwin, A.J.,Robinson, C.V.,Eisenberg, D.S.,Benesch, J.L.,Laganowsky, A.; The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity.; Proc.Natl.Acad.Sci.USA, 111:E1562-E1570, 2014; PubMed: 24711386; DOI: 10.1073/pnas.1322673111

Experimental method

X-RAY DIFFRACTION (2.599 Å)