Summary for 4MJ2
Entry DOI | 10.2210/pdb4mj2/pdb |
Related | 4KGJ 4KGL 4KH2 4MJ4 |
Descriptor | Alpha-L-iduronidase, S,R MESO-TARTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | tim barrel, beta sandwich, fibronectin type iii, hydrolyze iduronic acids from the non-reducing ends of glycosaminoglycan, intracellular, lysosomal, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P35475 |
Total number of polymer chains | 2 |
Total formula weight | 150050.28 |
Authors | Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N.G. (deposition date: 2013-09-03, release date: 2013-09-18, Last modification date: 2020-07-29) |
Primary citation | Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N. Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase. Nat.Chem.Biol., 9:739-745, 2013 Cited by PubMed: 24036510DOI: 10.1038/nchembio.1357 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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