4MJ2

Crystal structure of apo-iduronidase in the R3 form

Replaces:  4JXO

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Alpha-L-iduronidase	polymer	653	72688.6	2	UniProt (P35475) Pfam (PF01229) Pfam (PF21200) In PDB	Homo sapiens (human)
2	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
3	D	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4	E	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
5	F	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	1	In PDB GlyTouCan (G23799GS)
6	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	A, B	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
8	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
9	B	L(+)-TARTARIC ACID	non-polymer		150.1	2	Chemie (TLA)
10	B	S,R MESO-TARTARIC ACID	non-polymer		150.1	1	Chemie (SRT)
11		water	water		18.0	433	Chemie (HOH)

Sequence modifications

A, B: 1 - 653 (UniProt: P35475)

PDB	External Database	Details
Gln 33	His 33	SEE REMARK 999
Pro 63	Gln 63	SEE REMARK 999
Gln 105	Arg 105	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	145377.3
Branched	Number of molecules	4
	Total formula weight	3156.9
Non-Polymers*	Number of molecules	13
	Total formula weight	1516.1
All*	Total formula weight	150050.3

*Water molecules are not included.