4MGJ

Crystal structure of cytochrome P450 2B4 F429H in complex with 4-CPI

4MGJ の概要

• エントリーDOI: 10.2210/pdb4mgj/pdb
• 関連するPDBエントリー: 4MGL 4MGO
• 分子名称: Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: p450 fold, closed conformation, 4-cpi binding, oxidoreductase
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54965.19

構造登録者

Yang, Y.,Zhang, H.,Usharani, D.,Bu, W.,Im, S.,Tarasev, M.,Rwere, F.,Meagher, J.,Sun, C.,Stuckey, J.,Shaik, S.,Waskell, L. (登録日: 2013-08-28, 公開日: 2014-08-13, 最終更新日: 2024-02-28)

• 主引用文献: Yang, Y.,Zhang, H.,Usharani, D.,Bu, W.,Im, S.,Tarasev, M.,Rwere, F.,Pearl, N.M.,Meagher, J.,Sun, C.,Stuckey, J.,Shaik, S.,Waskell, L.; Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate-Histidine Hydrogen Bond.; Biochemistry, 53:5080-5091, 2014; PubMed: 25029089; DOI: 10.1021/bi5003794

実験手法

X-RAY DIFFRACTION (2.41 Å)