4MCD

hinTrmD in complex with 5-PHENYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

Summary for 4MCD

Entry DOI	10.2210/pdb4mcd/pdb
Related	4mcb 4mcc
Descriptor	tRNA (guanine-N(1)-)-methyltransferase, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one (3 entities in total)
Functional Keywords	trefoil, trmd, sam, sah, sinefungin, hmt, structural genomics, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Haemophilus influenzae Rd KW20
Cellular location	Cytoplasm (Potential): P43912
Total number of polymer chains	1
Total formula weight	27806.92
Authors	Lahiri, S. (deposition date: 2013-08-21, release date: 2013-09-25, Last modification date: 2024-02-28)
Primary citation	Hill, P.J.,Abibi, A.,Albert, R.,Andrews, B.,Gagnon, M.M.,Gao, N.,Grebe, T.,Hajec, L.I.,Huang, J.,Livchak, S.,Lahiri, S.D.,McKinney, D.C.,Thresher, J.,Wang, H.,Olivier, N.,Buurman, E.T. Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain. J.Med.Chem., 56:7278-7288, 2013 Cited by PubMed: 23981144 DOI: 10.1021/jm400718n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation