4MBK

Crystal structure of K234R inhibitor-resistant variant of SHV beta-lactamase in complex with SA2-13

Summary for 4MBK

• Entry DOI: 10.2210/pdb4mbk/pdb
• Related: 2H5S 4MBF 4MBH
• Descriptor: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, ... (4 entities in total)
• Functional Keywords: class a beta-lactamase, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 30317.59

Authors

Rodkey, E.A.,van den Akker, F. (deposition date: 2013-08-19, release date: 2014-07-30, Last modification date: 2017-11-15)

• Primary citation: Rodkey, E.A.,Winkler, M.L.,Bethel, C.R.,Pagadala, S.R.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F.; Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.; Plos One, 9:e85892-e85892, 2014; PubMed: 24454944; DOI: 10.1371/journal.pone.0085892

Experimental method

X-RAY DIFFRACTION (1.46 Å)