4M0W

Crystal Structure of SARS-CoV papain-like protease C112S mutant in complex with ubiquitin

Summary for 4M0W

• Entry DOI: 10.2210/pdb4m0w/pdb
• Descriptor: Replicase polyprotein 1a, Ubiquitin, ZINC ION, ... (7 entities in total)
• Functional Keywords: papain-like protease-ubiquitin complex, protein hydrolase and deubiquitination, hydrolase-protein binding complex, hydrolase/protein binding
• Biological source: SARS coronavirus (SARS-CoV); More
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8; Ubiquitin: Cytoplasm (By similarity): P62992
• Total number of polymer chains: 2
• Total formula weight: 46214.76

Authors

Chou, C.-Y.,Chen, H.-Y.,Lai, H.-Y.,Cheng, S.-C.,Chou, Y.-W. (deposition date: 2013-08-02, release date: 2014-02-12, Last modification date: 2023-11-08)

• Primary citation: Chou, C.-Y.,Lai, H.-Y.,Chen, H.-Y.,Cheng, S.-C.,Cheng, K.-W.,Chou, Y.-W.; Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease; Acta Crystallogr.,Sect.D, 70:572-581, 2014; PubMed: 24531491; DOI: 10.1107/S1399004713031040

Experimental method

X-RAY DIFFRACTION (1.4 Å)