4M0W

Crystal Structure of SARS-CoV papain-like protease C112S mutant in complex with ubiquitin

4M0W の概要

• エントリーDOI: 10.2210/pdb4m0w/pdb
• 分子名称: Replicase polyprotein 1a, Ubiquitin, ZINC ION, ... (7 entities in total)
• 機能のキーワード: papain-like protease-ubiquitin complex, protein hydrolase and deubiquitination, hydrolase-protein binding complex, hydrolase/protein binding
• 由来する生物種: SARS coronavirus (SARS-CoV); 詳細
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8; Ubiquitin: Cytoplasm (By similarity): P62992
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46214.76

構造登録者

Chou, C.-Y.,Chen, H.-Y.,Lai, H.-Y.,Cheng, S.-C.,Chou, Y.-W. (登録日: 2013-08-02, 公開日: 2014-02-12, 最終更新日: 2023-11-08)

• 主引用文献: Chou, C.-Y.,Lai, H.-Y.,Chen, H.-Y.,Cheng, S.-C.,Cheng, K.-W.,Chou, Y.-W.; Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease; Acta Crystallogr.,Sect.D, 70:572-581, 2014; PubMed: 24531491; DOI: 10.1107/S1399004713031040

実験手法

X-RAY DIFFRACTION (1.4 Å)