4LZ7
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
Summary for 4LZ7
Entry DOI | 10.2210/pdb4lz7/pdb |
Related | 4LZ5 4LZ8 |
Descriptor | Glutamate receptor 2, ZINC ION, GLUTAMIC ACID, ... (5 entities in total) |
Functional Keywords | ampa receptor, allosteric modulator, transport protein |
Biological source | Rattus norvegicus (brown rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 3 |
Total formula weight | 92410.65 |
Authors | Pandit, J. (deposition date: 2013-07-31, release date: 2013-12-04, Last modification date: 2023-09-20) |
Primary citation | Patel, N.C.,Schwarz, J.,Hou, X.J.,Hoover, D.J.,Xie, L.,Fliri, A.J.,Gallaschun, R.J.,Lazzaro, J.T.,Bryce, D.K.,Hoffmann, W.E.,Hanks, A.N.,McGinnis, D.,Marr, E.S.,Gazard, J.L.,Hajos, M.,Scialis, R.J.,Hurst, R.S.,Shaffer, C.L.,Pandit, J.,O'Donnell, C.J. Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators. J.Med.Chem., 56:9180-9191, 2013 Cited by PubMed: 24215237DOI: 10.1021/jm401274b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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