4LY9
Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate
Summary for 4LY9
Entry DOI | 10.2210/pdb4ly9/pdb |
Descriptor | Glucokinase regulatory protein, IODIDE ION, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total) |
Functional Keywords | regulatory protein, disruptor ligand complex, sis domains, gkrp binds to gk, liver, carbohydrate binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): Q14397 |
Total number of polymer chains | 2 |
Total formula weight | 145766.50 |
Authors | Jordan, S.R. (deposition date: 2013-07-30, release date: 2013-11-20, Last modification date: 2024-02-28) |
Primary citation | Lloyd, D.J.,St Jean, D.J.,Kurzeja, R.J.,Wahl, R.C.,Michelsen, K.,Cupples, R.,Chen, M.,Wu, J.,Sivits, G.,Helmering, J.,Komorowski, R.,Ashton, K.S.,Pennington, L.D.,Fotsch, C.,Vazir, M.,Chen, K.,Chmait, S.,Zhang, J.,Liu, L.,Norman, M.H.,Andrews, K.L.,Bartberger, M.D.,Van, G.,Galbreath, E.J.,Vonderfecht, S.L.,Wang, M.,Jordan, S.R.,Veniant, M.M.,Hale, C. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature, 504:437-440, 2013 Cited by PubMed: 24226772DOI: 10.1038/nature12724 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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