4LY9
Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucokinase regulatory protein | polymer | 637 | 70249.6 | 2 | UniProt (Q14397) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741) | Homo sapiens (human) | Glucokinase regulator |
| 2 | AA, BA, C, CA, D... (B, A) | IODIDE ION | non-polymer | 126.9 | 26 | Chemie (IOD) PubChem (30165) | |||
| 3 | FA, O (B, A) | D-SORBITOL-6-PHOSPHATE | non-polymer | 262.2 | 2 | Chemie (S6P) PubChem (618) PubChem (21968234) PubChem (130418) PubChem (152306) PubChem (17754155) PubChem (440969) PubChem (445703) PubChem (53827506) PubChem (92177220) PubChem (14620017) PubChem (92209470) PubChem (124335010) PubChem (163321747) PubChem (165361689) | |||
| 4 | GA, P (B, A) | (2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol | non-polymer | 533.6 | 2 | Chemie (1YY) PubChem (56933046) PubChem (66582820) PubChem (66582921) PubChem (66583294) PubChem (66584885) PubChem (66584886) PubChem (70655675) PubChem (66582747) PubChem (101880554) | |||
| 5 | HA, Q (B, A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 6 | IA, JA (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 7 | KA, LA (A, B) | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 625 (UniProt: Q14397)
| PDB | External Database | Details |
|---|---|---|
| Met -11 | - | expression tag |
| Ala -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Glu -2 | - | expression tag |
| Val -1 | - | expression tag |
| Asp 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140499.1 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 5267.4 | |
| All* | Total formula weight | 145766.5 |
