4LY9
Human GKRP complexed to AMG-1694 [(2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol] and sorbitol-6-phosphate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glucokinase regulatory protein | polymer | 637 | 70249.6 | 2 | UniProt (Q14397) Pfam (PF20741) In PDB | Homo sapiens (human) | Glucokinase regulator |
2 | B, A | IODIDE ION | non-polymer | 126.9 | 26 | Chemie (IOD) | |||
3 | B, A | D-SORBITOL-6-PHOSPHATE | non-polymer | 262.2 | 2 | Chemie (S6P) | |||
4 | B, A | (2R)-1,1,1-trifluoro-2-{4-[(2S)-2-{[(3S)-3-methylmorpholin-4-yl]methyl}-4-(thiophen-2-ylsulfonyl)piperazin-1-yl]phenyl}propan-2-ol | non-polymer | 533.6 | 2 | Chemie (1YY) | |||
5 | B, A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
6 | B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 625 (UniProt: Q14397)
PDB | External Database | Details |
---|---|---|
Met -11 | - | expression tag |
Ala -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Asp -3 | - | expression tag |
Glu -2 | - | expression tag |
Val -1 | - | expression tag |
Asp 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 140499.1 | |
Non-Polymers* | Number of molecules | 34 |
Total formula weight | 5267.4 | |
All* | Total formula weight | 145766.5 |