4LV4

A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase

4LV4 の概要

• エントリーDOI: 10.2210/pdb4lv4/pdb
• 関連するPDBエントリー: 3EKL 3EKZ 3ELF 4A21 4A22 4DEF 4DEL
• 分子名称: Fructose-bisphosphate aldolase, ZINC ION, 8-hydroxyquinoline-2-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: class ii fructose-1, 6-bisphosphate aldolase, zinc enzyme, mycobacterium tuberculosis, dihydroxyacetone, glyceraldehyde-3-phosphate, aldol condensation, glycolysis, lyase, metal-binding, 8-hydroxyquinoline-2-carboxylic acid, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37952.46

構造登録者

Capodagli, G.C.,Pegan, S.D. (登録日: 2013-07-25, 公開日: 2014-01-08, 最終更新日: 2023-09-20)

• 主引用文献: Capodagli, G.C.,Sedhom, W.G.,Jackson, M.,Ahrendt, K.A.,Pegan, S.D.; A Noncompetitive Inhibitor for Mycobacterium tuberculosis's Class IIa Fructose 1,6-Bisphosphate Aldolase.; Biochemistry, 53:202-213, 2014; PubMed: 24325645; DOI: 10.1021/bi401022b

実験手法

X-RAY DIFFRACTION (2.08 Å)