4LTC

Crystal structure of yeast 20S proteasome in complex with enone carmaphycin analogue 6

Summary for 4LTC

• Entry DOI: 10.2210/pdb4ltc/pdb
• Related: 4HNP 4HRC 4HRD
• Related PRD ID: PRD_001161
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (16 entities in total)
• Functional Keywords: proteasome, inhibitor, carmaphycin, epoxyketone, vinylketone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 729331.09

Authors

Stein, M.,Trivella, D.B.B.,Groll, M. (deposition date: 2013-07-23, release date: 2014-07-02)

• Primary citation: Trivella, D.B.,Pereira, A.R.,Stein, M.L.,Kasai, Y.,Byrum, T.,Valeriote, F.A.,Tantillo, D.J.,Groll, M.,Gerwick, W.H.,Moore, B.S.; Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor.; Chem.Biol., 21:782-791, 2014; PubMed: 24930969; DOI: 10.1016/j.chembiol.2014.04.010

Experimental method

X-RAY DIFFRACTION (2.5 Å)