4LSJ

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine Sulfonamide

4LSJ の概要

• エントリーDOI: 10.2210/pdb4lsj/pdb
• 分子名称: Glucocorticoid receptor, D30 peptide, N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide, ... (4 entities in total)
• 機能のキーワード: nuclear hormone receptor, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm. Isoform Beta: Nucleus: P04150
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32388.69

構造登録者

Carson, M.,Luz, J.G.,Clawson, D.,Coghlan, M. (登録日: 2013-07-22, 公開日: 2014-01-29, 最終更新日: 2024-02-28)

• 主引用文献: Carson, M.W.,Luz, J.G.,Suen, C.,Montrose, C.,Zink, R.,Ruan, X.,Cheng, C.,Cole, H.,Adrian, M.D.,Kohlman, D.T.,Mabry, T.,Snyder, N.,Condon, B.,Maletic, M.,Clawson, D.,Pustilnik, A.,Coghlan, M.J.; Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.; J.Med.Chem., 57:849-860, 2014; PubMed: 24446728; DOI: 10.1021/jm401616g

実験手法

X-RAY DIFFRACTION (2.35 Å)