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4LRM

EGFR D770_N771insNPG in complex with PD168393

Summary for 4LRM
Entry DOI10.2210/pdb4lrm/pdb
Related2J5F 4LL0 4LQM
DescriptorEpidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide (3 entities in total)
Functional Keywordsegfr, kinase, pd168393, 34-jab, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains5
Total formula weight191359.73
Authors
Yun, C.H.,Eck, M.J. (deposition date: 2013-07-20, release date: 2014-01-15, Last modification date: 2023-09-20)
Primary citationYasuda, H.,Park, E.,Yun, C.H.,Sng, N.J.,Lucena-Araujo, A.R.,Yeo, W.L.,Huberman, M.S.,Cohen, D.W.,Nakayama, S.,Ishioka, K.,Yamaguchi, N.,Hanna, M.,Oxnard, G.R.,Lathan, C.S.,Moran, T.,Sequist, L.V.,Chaft, J.E.,Riely, G.J.,Arcila, M.E.,Soo, R.A.,Meyerson, M.,Eck, M.J.,Kobayashi, S.S.,Costa, D.B.
Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer.
Sci Transl Med, 5:216ra177-216ra177, 2013
Cited by
PubMed: 24353160
DOI: 10.1126/scitranslmed.3007205
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.526 Å)
Structure validation

217705

数据于2024-03-27公开中

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