Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4LRM

EGFR D770_N771insNPG in complex with PD168393

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE YUN A 1101

Chain	Residue
A	LEU718
A	CYS800
A	ASP803
A	LEU847
A	THR857
A	ALA743
A	LYS745
A	LEU791
A	THR793
A	GLN794
A	LEU795
A	MET796
A	GLY799

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE YUN B 1101

Chain	Residue
B	ALA743
B	LYS745
B	LEU791
B	THR793
B	LEU795
B	MET796
B	GLY799
B	CYS800
B	ASP803
B	ARG844
B	LEU847
B	THR857

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE YUN C 1101

Chain	Residue
C	ALA743
C	ILE744
C	LYS745
C	LEU791
C	THR793
C	GLN794
C	LEU795
C	MET796
C	GLY799
C	CYS800
C	LEU847
C	THR857

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE YUN D 1101

Chain	Residue
D	ALA743
D	LYS745
D	LEU791
D	THR793
D	GLN794
D	LEU795
D	MET796
D	GLY799
D	CYS800
D	LEU847
D	THR857

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE YUN E 1101

Chain	Residue
E	LEU718
E	ALA743
E	LYS745
E	LEU791
E	THR793
E	GLN794
E	LEU795
E	MET796
E	GLY799
E	CYS800
E	ARG844
E	LEU847
E	THR857

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK

Chain	Residue	Details
A	LEU718-LYS745

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV

Chain	Residue	Details
A	LEU836-VAL848

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP840
B	ASP840
C	ASP840
D	ASP840
E	ASP840

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
A	LEU718
B	LEU718
C	LEU718
D	LEU718
E	LEU718

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:3VJO, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
A	LYS745
B	LYS745
C	LYS745
D	LYS745
E	LYS745

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:2ITV, ECO:0007744\|PDB:2ITX, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:3VJO, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIX, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
A	THR793
B	THR793
C	THR793
D	THR793
E	THR793

site_id	SWS_FT_FI5
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:2ITV, ECO:0007744\|PDB:2ITX, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIX, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
A	ASP858
B	ASP858
C	ASP858
D	ASP858
E	ASP858

site_id	SWS_FT_FI6
Number of Residues	5
Details	SITE: Important for interaction with PIK3C2B

Chain	Residue	Details
A	TYR1019
B	TYR1019
C	TYR1019
D	TYR1019
E	TYR1019

site_id	SWS_FT_FI7
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:3138233, ECO:0007744\|PubMed:18691976

Chain	Residue	Details
A	SER695
B	SER695
C	SER695
D	SER695
E	SER695

site_id	SWS_FT_FI8
Number of Residues	5
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269\|PubMed:29192674

Chain	Residue	Details
A	LYS745
B	LYS745
C	LYS745
D	LYS745
E	LYS745

site_id	SWS_FT_FI9
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:23774213

Chain	Residue	Details
A	TYR872
B	TYR872
C	TYR872
D	TYR872
E	TYR872

site_id	SWS_FT_FI10
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:16083266, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER994
B	SER994
C	SER994
D	SER994
E	SER994

site_id	SWS_FT_FI11
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	SER998
B	SER998
C	SER998
D	SER998
E	SER998

site_id	SWS_FT_FI12
Number of Residues	5
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269\|PubMed:19563760, ECO:0007744\|PubMed:18669648

Chain	Residue	Details
A	TYR1001
B	TYR1001
C	TYR1001
D	TYR1001
E	TYR1001

site_id	SWS_FT_FI13
Number of Residues	5
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269\|PubMed:19563760, ECO:0000269\|PubMed:23774213

Chain	Residue	Details
A	TYR1019
B	TYR1019
C	TYR1019
D	TYR1019
E	TYR1019

site_id	SWS_FT_FI14
Number of Residues	20
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:33996800

Chain	Residue	Details
A	LYS716
C	LYS737
C	LYS754
C	LYS870
D	LYS716
D	LYS737
D	LYS754
D	LYS870
E	LYS716
E	LYS737
E	LYS754
A	LYS737
E	LYS870
A	LYS754
A	LYS870
B	LYS716
B	LYS737
B	LYS754
B	LYS870
C	LYS716

site_id	SWS_FT_FI15
Number of Residues	15
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144

Chain	Residue	Details
D	LYS932
D	LYS973
E	LYS932
E	LYS973
A	LYS932
A	LYS973
B	LYS932
B	LYS973
C	LYS932
C	LYS973

site_id	SWS_FT_FI16
Number of Residues	10
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:33996800

Chain	Residue	Details
A	LYS757
E	LYS963
A	LYS963
B	LYS757
B	LYS963
C	LYS757
C	LYS963
D	LYS757
D	LYS963
E	LYS757

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)