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4LQI

Yeast 20S Proteasome in complex with Vibralactone

Summary for 4LQI
Entry DOI10.2210/pdb4lqi/pdb
Related1RYP 2FAK 3E47
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (16 entities in total)
Functional Keywordsbeta-lactone, inhibitor, natural product, target identification, ntn-protease, cellular protein degradation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
More
Cellular locationCytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains28
Total formula weight705047.32
Authors
List, A.,Zeiler, E.,Gallastegui, N.,Rusch, M.,Hedberg, C.,Sieber, S.A.,Groll, M. (deposition date: 2013-07-18, release date: 2013-12-25, Last modification date: 2023-09-20)
Primary citationList, A.,Zeiler, E.,Gallastegui, N.,Rusch, M.,Hedberg, C.,Sieber, S.A.,Groll, M.
Omuralide and Vibralactone: Differences in the Proteasome-beta-Lactone-gamma-Lactam Binding Scaffold Alter Target Preferences.
Angew.Chem.Int.Ed.Engl., 53:571-574, 2014
Cited by
PubMed: 24285701
DOI: 10.1002/anie.201308567
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

건을2024-03-27부터공개중

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