4LQI

Yeast 20S Proteasome in complex with Vibralactone

4LQI の概要

• エントリーDOI: 10.2210/pdb4lqi/pdb
• 関連するPDBエントリー: 1RYP 2FAK 3E47
• 分子名称: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (16 entities in total)
• 機能のキーワード: beta-lactone, inhibitor, natural product, target identification, ntn-protease, cellular protein degradation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 705047.32

構造登録者

List, A.,Zeiler, E.,Gallastegui, N.,Rusch, M.,Hedberg, C.,Sieber, S.A.,Groll, M. (登録日: 2013-07-18, 公開日: 2013-12-25, 最終更新日: 2023-09-20)

• 主引用文献: List, A.,Zeiler, E.,Gallastegui, N.,Rusch, M.,Hedberg, C.,Sieber, S.A.,Groll, M.; Omuralide and Vibralactone: Differences in the Proteasome-beta-Lactone-gamma-Lactam Binding Scaffold Alter Target Preferences.; Angew.Chem.Int.Ed.Engl., 53:571-574, 2014; PubMed: 24285701; DOI: 10.1002/anie.201308567

実験手法

X-RAY DIFFRACTION (2.7 Å)