Summary for 4LL3
Entry DOI | 10.2210/pdb4ll3/pdb |
Related | 3QOZ |
Descriptor | Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total) |
Functional Keywords | hydrolase inhibitor-darunavir, hydrolase-hydrolase inhibitor complex, hiv-1 protease, tmc114, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22756.89 |
Authors | Grantz Saskova, K.,Rezacova, P.,Brynda, J.,Kozisek, M.,Konvalinka, J. (deposition date: 2013-07-09, release date: 2014-04-16, Last modification date: 2024-02-28) |
Primary citation | Kozisek, M.,Lepsik, M.,Grantz Saskova, K.,Brynda, J.,Konvalinka, J.,Rezacova, P. Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases. Febs J., 281:1834-1847, 2014 Cited by PubMed: 24785545DOI: 10.1111/febs.12743 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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