4LL3

Structure of wild-type HIV protease in complex with darunavir

Replaces:  3QOZ

Summary for 4LL3

• Entry DOI: 10.2210/pdb4ll3/pdb
• Related: 3QOZ
• Descriptor: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• Functional Keywords: hydrolase inhibitor-darunavir, hydrolase-hydrolase inhibitor complex, hiv-1 protease, tmc114, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22756.89

Authors

Grantz Saskova, K.,Rezacova, P.,Brynda, J.,Kozisek, M.,Konvalinka, J. (deposition date: 2013-07-09, release date: 2014-04-16, Last modification date: 2024-02-28)

• Primary citation: Kozisek, M.,Lepsik, M.,Grantz Saskova, K.,Brynda, J.,Konvalinka, J.,Rezacova, P.; Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases.; Febs J., 281:1834-1847, 2014; PubMed: 24785545; DOI: 10.1111/febs.12743

Experimental method

X-RAY DIFFRACTION (1.95 Å)