4LL3

Structure of wild-type HIV protease in complex with darunavir

Replaces:  3QOZ

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protease	polymer	99	10830.8	2	UniProt (Q9WFL7) Pfam (PF00077) UniProt (by SIFTS) (P03367)	Human immunodeficiency virus 1
2	C, D (A)	(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE	non-polymer		547.7	2	Chemie (017)
3	E, F (A, B)	water	water		18.0	141	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21661.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1095.3
All*	Total formula weight	22756.9

*Water molecules are not included.