4LK3

Crystal structure of Human UDP-xylose synthase R236A substitution

4LK3 の概要

• エントリーDOI: 10.2210/pdb4lk3/pdb
• 分子名称: UDP-glucuronic acid decarboxylase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIDINE-5'-DIPHOSPHATE, ... (7 entities in total)
• 機能のキーワード: short-chain dehydrogenase/reductase, decarboxylase, lyase, membrane, rossmann fold
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein : Q8NBZ7
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 237095.54

構造登録者

Walsh Jr., R.M.,Polizzi, S.J.,Wood, Z.A. (登録日: 2013-07-05, 公開日: 2013-08-07, 最終更新日: 2023-09-20)

• 主引用文献: Walsh Jr., R.M.,Polizzi, S.J.,Kadirvelraj, R.,Howard, W.W.,Wood, Z.A.; Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation.; Biochemistry, 54:807-819, 2015; PubMed: 25521717; DOI: 10.1021/bi501357c

実験手法

X-RAY DIFFRACTION (2.64 Å)