4LEO

Crystal structure of anti-HER3 Fab RG7116 in complex with the extracellular domains of human Her3 (ERBB3)

4LEO の概要

• エントリーDOI: 10.2210/pdb4leo/pdb
• 分子名称: RG7116 Fab heavy chain, RG7116 Fab light chain, Receptor tyrosine-protein kinase erbB-3, ... (6 entities in total)
• 機能のキーワード: fab fragment, therapeutic antibody, her3 receptor, transferase-immune system complex, transferase/immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 118509.99

構造登録者

Schiller, C.B.,Hopfner, K.P. (登録日: 2013-06-26, 公開日: 2013-07-10, 最終更新日: 2020-07-29)

• 主引用文献: Mirschberger, C.,Schiller, C.B.,Schraml, M.,Dimoudis, N.,Friess, T.,Gerdes, C.A.,Reiff, U.,Lifke, V.,Hoelzlwimmer, G.,Kolm, I.,Hopfner, K.P.,Niederfellner, G.,Bossenmaier, B.; RG7116, a Therapeutic Antibody That Binds the Inactive HER3 Receptor and Is Optimized for Immune Effector Activation.; Cancer Res., 73:5183-5194, 2013; PubMed: 23780344; DOI: 10.1158/0008-5472.CAN-13-0099

実験手法

X-RAY DIFFRACTION (2.64 Å)