4L9P

Crystal structure of Aspergillus fumigatus protein farnesyltransferase complexed with the FII analog, FPT-II, and the KCVVM peptide

4L9P の概要

• エントリーDOI: 10.2210/pdb4l9p/pdb
• 関連するPDBエントリー: 4LNB 4LNG
• 分子名称: CaaX farnesyltransferase alpha subunit Ram2, CaaX farnesyltransferase beta subunit Ram1, LYS-CYS-VAL-VAL-MET (CAAX peptide), ... (8 entities in total)
• 機能のキーワード: ternary complex with isoprenoid and caax peptide substrate, caax farnesyltransferase, isoprenoid and caax protein/peptide substrate, transferase
• 由来する生物種: Aspergillus fumigatus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 100696.84

構造登録者

Mabanglo, M.F.,Hast, M.A.,Beese, L.S. (登録日: 2013-06-18, 公開日: 2014-01-01, 最終更新日: 2024-04-03)

• 主引用文献: Mabanglo, M.F.,Hast, M.A.,Lubock, N.B.,Hellinga, H.W.,Beese, L.S.; Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.; Protein Sci., 23:289-301, 2014; PubMed: 24347326; DOI: 10.1002/pro.2411

実験手法

X-RAY DIFFRACTION (1.45 Å)