4L3E

The complex between high affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(26-35)(A27L) peptide

Summary for 4L3E

Entry DOI	10.2210/pdb4l3e/pdb
Related	3QDG 3QDJ 3QDM 3QEQ 3QEU
Descriptor	HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1, ... (6 entities in total)
Functional Keywords	receptors, membrane, immune system
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
Total number of polymer chains	5
Total formula weight	93775.09
Authors	Hellman, L.M. (deposition date: 2013-06-05, release date: 2014-06-11, Last modification date: 2014-08-27)
Primary citation	Pierce, B.G.,Hellman, L.M.,Hossain, M.,Singh, N.K.,Vander Kooi, C.W.,Weng, Z.,Baker, B.M. Computational design of the affinity and specificity of a therapeutic T cell receptor. PLOS COMPUT.BIOL., 10:e1003478-e1003478, 2014 Cited by PubMed: 24550723 DOI: 10.1371/journal.pcbi.1003478 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.557 Å)

Structure validation