4KZ9
Crystal structure of AmpC beta-lactamase in complex with fragment 41 ((4R,4aS,8aS)-4-phenyldecahydroquinolin-4-ol)
Summary for 4KZ9
| Entry DOI | 10.2210/pdb4kz9/pdb |
| Related | 4KZ3 4KZ4 4KZ5 4KZ6 4KZ7 4KZ8 4KZA 4KZB |
| Descriptor | Beta-lactamase, PHOSPHATE ION, (4R,4aS,8aS)-4-phenyldecahydroquinolin-4-ol, ... (4 entities in total) |
| Functional Keywords | ampc beta-lactamase, class c, hydrolase, cephalosporinase |
| Biological source | Escherichia coli |
| Cellular location | Periplasm: P00811 |
| Total number of polymer chains | 2 |
| Total formula weight | 79692.09 |
| Authors | Eidam, O.,Barelier, S.,Fish, I.,Shoichet, B.K. (deposition date: 2013-05-29, release date: 2014-05-21, Last modification date: 2023-09-20) |
| Primary citation | Barelier, S.,Eidam, O.,Fish, I.,Hollander, J.,Figaroa, F.,Nachane, R.,Irwin, J.J.,Shoichet, B.K.,Siegal, G. Increasing chemical space coverage by combining empirical and computational fragment screens. Acs Chem.Biol., 9:1528-1535, 2014 Cited by PubMed: 24807704DOI: 10.1021/cb5001636 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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