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4KZ4

Crystal structure of AmpC beta-lactamase in complex with fragment 60 (2-[(propylsulfonyl)amino]benzoic acid)

Summary for 4KZ4
Entry DOI10.2210/pdb4kz4/pdb
Related4KZ3 4KZ5 4KZ6 4KZ7 4KZ8 4KZ9 4KZA 4KZB
DescriptorBeta-lactamase, PHOSPHATE ION, 2-[(propylsulfonyl)amino]benzoic acid, ... (4 entities in total)
Functional Keywordsampc beta-lactamase, class c, hydrolase, cephalosporinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceEscherichia coli
Cellular locationPeriplasm: P00811
Total number of polymer chains2
Total formula weight79704.04
Authors
Eidam, O.,Barelier, S.,Fish, I.,Shoichet, B.K. (deposition date: 2013-05-29, release date: 2014-05-21, Last modification date: 2023-09-20)
Primary citationBarelier, S.,Eidam, O.,Fish, I.,Hollander, J.,Figaroa, F.,Nachane, R.,Irwin, J.J.,Shoichet, B.K.,Siegal, G.
Increasing chemical space coverage by combining empirical and computational fragment screens.
Acs Chem.Biol., 9:1528-1535, 2014
Cited by
PubMed: 24807704
DOI: 10.1021/cb5001636
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.42 Å)
Structure validation

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