4KXQ

Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 1.85 A)

Summary for 4KXQ

• Entry DOI: 10.2210/pdb4kxq/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-1, ZINC ION, ADENOSINE-5-DIPHOSPHORIBOSE, ... (7 entities in total)
• Functional Keywords: deacetylase, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus, PML body. SirtT1 75 kDa fragment: Cytoplasm: Q96EB6 Q96EB6
• Total number of polymer chains: 2
• Total formula weight: 36057.81

Authors

Davenport, A.M.,Huber, F.M.,Hoelz, A. (deposition date: 2013-05-27, release date: 2013-10-23, Last modification date: 2024-02-28)

• Primary citation: Davenport, A.M.,Huber, F.M.,Hoelz, A.; Structural and Functional Analysis of Human SIRT1.; J.Mol.Biol., 426:526-541, 2014; PubMed: 24120939; DOI: 10.1016/j.jmb.2013.10.009

Experimental method

X-RAY DIFFRACTION (1.849 Å)