4KXQ

Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 1.85 A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	NAD-dependent protein deacetylase sirtuin-1	polymer	281	31833.1	1	UniProt (Q96EB6) Pfam (PF02146) In PDB	Homo sapiens (human)	SIRT1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2
2	B	NAD-dependent protein deacetylase sirtuin-1	polymer	30	3429.7	1	UniProt (Q96EB6) In PDB	Homo sapiens (human)	SIRT1, hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	ADENOSINE-5-DIPHOSPHORIBOSE	non-polymer		559.3	1	Chemie (APR)
5	A	BETA-MERCAPTOETHANOL	non-polymer		78.1	1	Chemie (BME)
6	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7		water	water		18.0	300	Chemie (HOH)

Sequence modifications

A: 234 - 510 (UniProt: Q96EB6)

PDB	External Database	Details
Gly 230	-	expression tag
Pro 231	-	expression tag
His 232	-	expression tag
Met 233	-	expression tag

B: 641 - 663 (UniProt: Q96EB6)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
His -4	-	expression tag
Met -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Val 664	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35262.9
Non-Polymers*	Number of molecules	4
	Total formula weight	795.0
All*	Total formula weight	36057.8

*Water molecules are not included.