4KSH

Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)

4KSH の概要

• エントリーDOI: 10.2210/pdb4ksh/pdb
• 関連するPDBエントリー: 4GEE 4K4O 4KFG 4KSG 4KTN
• 分子名称: DNA gyrase subunit B, 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)-1,5-naphthyridin-1(4H)-ol, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna rings, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Enterococcus faecalis
• 細胞内の位置: Cytoplasm (By similarity): Q839Z1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24371.66

構造登録者

Bensen, D.C.,Akers-Rodriguez, S.,Tari, L.W. (登録日: 2013-05-17, 公開日: 2014-01-15, 最終更新日: 2024-02-28)

• 主引用文献: Tari, L.W.,Bensen, D.C.,Finn, J.; A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity; To be Published,

実験手法

X-RAY DIFFRACTION (1.7 Å)